(R)-(+)-1-Phenylethylamine CAS 3886-69-9

(R)-(+)-1-Phenylethylamine Applications

(R)-(+)-1-Phenylethylamine (also known as (R)-(+)-α-Methylbenzylamine or D-(+)-α-Methylbenzylamine) is a versatile chiral amine widely used in organic synthesis and pharmaceutical research. Its main applications include:

• Chiral resolving agent: Used for the resolution of racemic acids or racemic mixtures by forming diastereomeric salts, enabling the separation of enantiomers. It is particularly effective for resolving chiral acids and determining the enantiomeric purity of acidic compounds.
• Chiral auxiliary in asymmetric synthesis: Serves as a key building block and chiral inducer in the stereoselective synthesis of enantiomerically pure compounds, including pharmaceuticals and agrochemicals.
• Intermediate in pharmaceutical manufacturing: Employed in the synthesis of chiral drugs, such as the HIV protease inhibitor nelfinavir, and other biologically active molecules where enantiomeric purity is critical for efficacy and safety.
• Chiral derivatization reagent: Applied in analytical chemistry (e.g., GC or HPLC) for determining optical purity through the formation of diastereomers.
• Other uses: Acts as a chiral catalyst or ligand in certain organic reactions and is utilized in the preparation of specialty chemicals.

(R)-(+)-1-Phenylethylamine Packaging and Shipping

• Packaging: Typically supplied in glass bottles or drums with secure, airtight seals to prevent air and moisture exposure. Common sizes range from 25 mL to 250 kg, depending on supplier (e.g., 100 g, 500 g, or bulk). Packaged under inert gas (nitrogen or argon) for high-purity grades to maintain stability.
• Shipping: Classified as a hazardous material (UN 2735, Amines, liquid, corrosive, n.o.s., Class 8, Packing Group II or III). Shipped in compliance with IATA/DOT/IMDG regulations for corrosive and harmful liquids. Requires proper labeling (corrosive + harmful), secondary containment, and temperature-controlled transport if needed. Must be handled with care to avoid leaks; not eligible for standard air freight without proper declaration.

Storage

• Store in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and strong light.
• Keep container tightly closed and under inert gas (nitrogen or argon) to protect from air and moisture, as the compound is air-sensitive and hygroscopic.
• Recommended storage temperature: Ambient or refrigerated (2–8 °C for long-term stability).
• Keep locked up and separated from incompatible materials (e.g., strong oxidizing agents, acids, CO₂).
• Shelf life is typically extended when stored properly under inert conditions.