Chemical Name: COMBRETASTATIN A-4
CAS No.: 117048-59-6
Molecular Formula: C18H20O5
Molecular Weight: 316.35
COMBRETASTATIN A-4 CAS 117048-59-6
Description
COMBRETASTATIN A-4
Chemical Name: COMBRETASTATIN A-4
CAS No.: 117048-59-6
Molecular Formula: C18H20O5
Molecular Weight: 316.35
COMBRETASTATIN A-4 Chemical Properties
| Melting point | 84.5-85.5°C |
| Boiling point | 490.3±45.0 °C(Predicted) |
| density | 1.184±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >10mg/mL |
| pka | 9.65±0.10(Predicted) |
| form | powder |
| color | off-white |
| SMILES | C1(O)=CC(/C=CC2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC |
COMBRETASTATIN A-4 Chemical Properties,Uses
Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin
Combretastatin A4 has been used:
- as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase.
- to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models.
- as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae.