1H-Pyrrolo[2,3-B]Pyridin-5-Ol CAS 98549-88-3

Description

1H-Pyrrolo[2,3-B]Pyridin-5-Ol Quick Details

Chemical Name: 1H-Pyrrolo[2,3-B]Pyridin-5-Ol

Cas No.: 98549-88-3

Molecular Fomula: C7H6N2O

Molecular Weight: 134.14

Appearance: White Powder

Assay：≥99.0%

1H-Pyrrolo[2,3-B]Pyridin-5-Ol Typical Properties

Items	Specification
Appearance	White Powder
Purity	≥99.0%

Product Introduction:

1H-Pyrrolo[2,3-B]Pyridin-5-Ol is a fused bicyclic heterocyclic compound, often referred to as a 5-hydroxy-7-azaindole derivative. It combines a pyrrole ring fused with a pyridine ring, with a hydroxyl group at the 5-position. It typically appears as a white to off-white crystalline powder.

This compound is a highly valuable and sophisticated building block in organic synthesis, particularly in medicinal chemistry, due to the presence of both the biologically significant 7-azaindole (pyrrolo[2,3-b]pyridine) core and the reactive hydroxyl group. The azaindole scaffold is a known pharmacophore in many active pharmaceutical ingredients.

Main Uses:

1. Pharmaceutical Intermediates and Medicinal Chemistry: This compound is primarily used as a key intermediate in the synthesis of numerous pharmaceutical active ingredients (APIs) and drug candidates. The 7-azaindole core is found in drugs targeting various diseases, including kinase inhibitors, anti-cancer agents, and neurological drugs. The hydroxyl group provides a versatile site for further functionalization, such as etherification, esterification, or various coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce diverse side chains and modify pharmacological properties.

2. Organic Synthesis: It serves as a versatile reagent in complex organic synthesis. The hydroxyl group can be readily transformed, and the aromatic rings can undergo electrophilic substitution or transition metal-catalyzed cross-coupling reactions, allowing for the construction of highly complex and substituted heterocyclic systems.

3. Research and Development: It is extensively used in academic and industrial research for the synthesis of new chemical entities (NCEs), lead optimization, and the development of new synthetic methodologies, particularly in the field of heterocyclic chemistry.

4. Agrochemical Intermediates: Similar complex heterocyclic structures with reactive groups can also find applications as intermediates in the synthesis of advanced agrochemicals, where specific structural motifs are required for biological activity.

1H-Pyrrolo[2,3-B]Pyridin-5-Ol Packaging And Shipping 

25Kg/Drum

1H-Pyrrolo[2,3-B]Pyridin-5-Ol Storage

It Should Be Stored In a Clean, Dry And Cool Place, Preventing From Sunlight, Rain.