Benzo[b]Thiophene, 2-[(5-Bromo-2-Fluorophenyl)Methyl]- CAS 1034305-17-3

Description

Benzo[b]Thiophene, 2-[(5-Bromo-2-Fluorophenyl)Methyl]- Quick Details

Chemical Name: Benzo[b]Thiophene, 2-[(5-Bromo-2-Fluorophenyl)Methyl]-

Cas No.:1034305-17-3

Molecular Fomula: C15H10Brfs

Molecular Weight: 321.21

Appearance: White To Pale Yellow Powder

Assay：≥99.0%

Benzo[b]Thiophene, 2-[(5-Bromo-2-Fluorophenyl)Methyl]- Typical Properties

Items	Specification
Appearance	White To Pale Yellow Powder
Purity	≥99.0%

Product Introduction:

2-[(5-Bromo-2-Fluorophenyl)Methyl]benzo[b]thiophene is a complex organic compound featuring a benzo[b]thiophene core substituted with a brominated and fluorinated benzyl group. It typically appears as a white to off-white crystalline powder.

This compound is a highly specialized and sophisticated building block, particularly valuable in medicinal chemistry due to the presence of multiple reactive sites and the combination of halogenated aryl rings with a sulfur-containing heterocycle. This structure offers a rich platform for further functionalization and serves as a key motif in the development of new chemical entities.

Main Uses:

1. Pharmaceutical Intermediates and Medicinal Chemistry: This compound is primarily used as a crucial intermediate in the synthesis of advanced pharmaceutical active ingredients (APIs). The benzo[b]thiophene scaffold is present in numerous biologically active molecules, and the bromo- and fluoro-substituted phenylmethyl group provides opportunities for various cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to introduce further complexity and achieve desired pharmacological profiles. It is vital for drug discovery and lead optimization efforts.

2. Organic Synthesis: It serves as a versatile reagent in complex organic synthesis. The bromine atom can undergo transition metal-catalyzed coupling reactions, while the fluorine atom can modulate electronic properties or serve as a site for further modification (e.g., for PET imaging). The benzylic position on the methylene bridge also offers potential for reactivity.

3. Research and Development: It is extensively used in academic and industrial research for the synthesis of new chemical entities, combinatorial chemistry, and the development of novel synthetic routes towards complex drug-like molecules.

4. Agrochemical Intermediates: Similar complex halogenated heterocycles can also find applications as intermediates in the synthesis of advanced agrochemicals, where specific structural motifs are required for biological activity.

Benzo[b]Thiophene, 2-[(5-Bromo-2-Fluorophenyl)Methyl]-  Packaging And Shipping 

25Kg/Drum

Benzo[b]Thiophene, 2-[(5-Bromo-2-Fluorophenyl)Methyl]-  Storage

It Should Be Stored In a Clean, Dry And Cool Place, Preventing From Sunlight, Rain.