Assay: ≥98%
Appearance: White to off-white crystalline powder
Packaging: 1kg/bag, 25kg/drum (Customizable)
Sample: Available
Methyl 5-(Tert-Butoxycarbonyl(Methyl)Amino)Thiophene-2-Carboxylate CAS 1174316-17-6
Description
Methyl 5-(Tert-Butoxycarbonyl(Methyl)Amino)Thiophene-2-Carboxylate Quick Details
Chemical Name: Methyl 5-(Tert-Butoxycarbonyl(Methyl)Amino)Thiophene-2-Carboxylate
Cas No.1174316-17-6
Molecular Fomula:C12H17No4S
Molecular Weight:271.33
Typical Properties
| Items | Specification |
| Density | 1.209±0.06 g/Cm3(Predicted) |
| Boiling Point | 368.9±27.0 °C(Predicted) |
| Acidity Coefficient (Pka) | -2.83 ± 0.50 (Predicted)) |
Product Introduction:
Methyl 5-(Tert-Butoxycarbonyl(Methyl)Amino)Thiophene-2-Carboxylate is a highly functionalized thiophene derivative. It combines a thiophene ring with a methyl ester group, and a protected secondary amine (N-methyl-N-Boc-amino) group. It typically appears as a white to off-white crystalline powder.
This compound is a sophisticated building block in organic synthesis, particularly valuable in medicinal chemistry due to the presence of multiple reactive and modifiable functional groups, and the biologically relevant thiophene scaffold. The Boc (tert-butoxycarbonyl) group serves as a common protecting group for the amine, allowing for selective reactions.
Main Uses:
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Pharmaceutical Intermediates and Medicinal Chemistry: This compound is primarily used as a key intermediate in the synthesis of complex pharmaceutical active ingredients (APIs). The thiophene ring is a common pharmacophore in many drug molecules, and the protected amine and ester groups provide versatile handles for further derivatization, cyclization, and coupling reactions to build drug candidates.
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Organic Synthesis: It serves as a versatile reagent in general organic synthesis. The ester group can be hydrolyzed or transformed into other carbonyl derivatives, while the Boc-protected amine can be deprotected to yield a free secondary amine for further reactions (e.g., amidation, alkylation). The thiophene ring can also undergo electrophilic aromatic substitution or cross-coupling reactions.
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Research and Development: It is widely used in academic and industrial research for the synthesis of new chemical entities (NCEs), lead optimization, and the development of new synthetic methodologies.
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Agrochemical Intermediates: While primarily pharmaceutical, similar highly functionalized heterocycles can also find application as intermediates in the synthesis of advanced agrochemicals.
Packaging And Shipping
Customized According To Customer Needs.
Storage
Sealed In Dry,Room Temperature.