Assay: ??99.0%
Appearance: Light yellow crystalline powder
Packaging: Customized according to customer needs.
Sample: available
Pyronaridine CAS 74847-35-1
Description
Pyronaridine Details
Chemical Name:?Pyronaridine
CAS No.:74847-35-1
Molecular Fomula: C29H32ClN5O2
Chemical Structure:
Molecular weight:518.05
Appearance: Light yellow crystalline powder
Assay????99.0
Pyronaridine?Typical Properties
| ITEMS | SPECIFICATION |
| Refractive index | 1.5650 (estimate) |
| Acidity coefficient (pKa) | 8.20??0.50(Predicted) |
| boiling point | 621.3??55.0 ??C(Predicted) |
| density | 1.356??0.06 g/cm3 (20?? 760 Torr) |
Product Description:
Pyronaridine is a synthetic antimalarial drug belonging to the class of tetrahydropyrazinoquinoline derivatives. It is typically supplied as a yellow crystalline powder, often used in the form of its phosphate salt.
Pyronaridine is a potent and fast-acting blood schizonticidal agent effective against various species of?Plasmodium, particularly?Plasmodium falciparum, including chloroquine-resistant and multi-drug-resistant strains.
Its mechanism of action is believed to involve the inhibition of hemozoin formation (a detoxification pathway for heme in malaria parasites) and interference with parasite metabolism, leading to parasite death. Pyronaridine is increasingly used in combination therapies (e.g., with artesunate) to enhance efficacy and prevent resistance.
Key Applications:
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Antimalarial Drug:?A critical active pharmaceutical ingredient (API) for the treatment of uncomplicated and severe malaria, especially in regions with high drug resistance.
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Pharmaceutical Formulations:?Used in the manufacture of antimalarial tablets, often in fixed-dose combination therapies (ACTs) with other antimalarials.
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Research & Development:?Employed in pharmaceutical research for developing new antimalarial combination therapies and studying drug mechanisms and resistance profiles.
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Tropical Medicine:?A vital medication in global efforts to control and eliminate malaria, particularly in endemic areas.
Packaging and Shipping?
customized according to customer needs.
Storage
It should be stored in a clean, dry and cool place, preventing from sunlight, rain.